Application | Comment | Organism |
---|---|---|
drug development | development of a new series of thienopyrimidine-6-carboxylate inhibitors of the Campylobacter jejuni PglD UDP-amino-sugar acetyltransferase enzyme, which upon further optimization may lead to new agents with targeted antivirulence activity | Campylobacter jejuni subsp. jejuni |
Cloned (Comment) | Organism |
---|---|
heterologous expression in Escherichia coli BL-21(DE3) | Campylobacter jejuni subsp. jejuni |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-5-methyl-4-(methylamino)-thieno[2,3-d]pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
2-(2-acetamidophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
2-(3-acetamidophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
2-(3-chlorophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]-pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
2-(3-fluorophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]-pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
2-(3-methoxyphenethyl)-4-(methylamino)thieno[3,2-d]-pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
2-(3-methoxyphenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
2-(4-acetamidophenethyl)-4-((2-aminoethyl)amino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
2-(4-acetamidophenethyl)-5-methyl-4-((2-(pyridin-2-yl)ethyl)-amino)thieno[2,3-d]pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
2-(4-acetamidophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
4-( (2,3-dihydro-1H-inden-2-yl )amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
4-((2-(benzo[d][1,3]dioxol-5-yl)ethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
4-((2-aminoethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]-pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
4-((2-fluorophenethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
4-((2-methoxyphenethyl)amino)-5-methyl-2-phenethylthieno-[2,3-d]pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
4-((3,5-dimethoxyphenethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
4-((3-fluorophenethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
4-((3-methoxyphenethyl)amino)-5-methyl-2-phenethylthieno-[2,3-d]pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
4-((4-fluorophenethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
4-((4-methoxyphenethyl)amino)-5-methyl-2-phenethylthieno-[2,3-d]pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
4-(benzylamino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
4-(methylamino)-2-phenethylthieno[3,2-d]pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
5-methyl-2-phenethyl-4-((2-(pyridin-2-yl)ethyl)amino)thieno[2,3-d]pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
5-methyl-2-phenethyl-4-((2-(pyridin-3-yl)ethyl)amino)thieno[2,3-d]pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
5-methyl-2-phenethyl-4-((2-(pyridin-4-yl)ethyl)amino)thieno[2,3-d]pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
5-methyl-2-phenethyl-4-(phenethylamino)thieno[2,3-d]-pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
5-methyl-4-((2-methylphenethyl)amino)-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
5-methyl-4-((3-methylphenethyl)amino)-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
5-methyl-4-((4-methylphenethyl)amino)-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
5-methyl-4-(methylamino)-2-(2-(pyridin-2-yl)ethyl)thieno[2,3-d]-pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
5-methyl-4-(methylamino)-2-(3-(trifluoromethyl)phenethyl)-thieno[2,3-d]pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
5-methyl-4-(methylamino)-2-(3-phenylpropyl)thieno[2,3-d]-pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
5-methyl-4-(methylamino)-2-(4-phenylbutyl)thieno[2,3-d]-pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
5-methyl-4-(methylamino)-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid | - |
Campylobacter jejuni subsp. jejuni | |
ethyl (S)-2-(4-acetamidophenethyl)-4-((2-methoxy-2-phenylethyl)amino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylate | - |
Campylobacter jejuni subsp. jejuni | |
ethyl 4-(((R)-2-methoxy-2-phenylethyl)amino)-5-methyl-2-((R)-2-phenylpropyl)thieno[2,3-d]pyrimidine-6-carboxylate | - |
Campylobacter jejuni subsp. jejuni | |
ethyl 4-(((R)-2-methoxy-2-phenylethyl)amino)-5-methyl-2-((S)-2-phenylpropyl)thieno[2,3-d]pyrimidine-6-carboxylate | - |
Campylobacter jejuni subsp. jejuni | |
ethyl 4-(((S)-2-methoxy-2-phenylethyl)amino)-5-methyl-2-((R)-2-phenylpropyl)thieno[2,3-d]pyrimidine-6-carboxylate | - |
Campylobacter jejuni subsp. jejuni | |
ethyl 4-(((S)-2-methoxy-2-phenylethyl)amino)-5-methyl-2-((S)-2-phenylpropyl)thieno[2,3-d]pyrimidine-6-carboxylate | - |
Campylobacter jejuni subsp. jejuni |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Campylobacter jejuni subsp. jejuni | Q0P9D1 | - |
- |
Campylobacter jejuni subsp. jejuni NCTC 11168 | Q0P9D1 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Campylobacter jejuni subsp. jejuni |
Synonyms | Comment | Organism |
---|---|---|
PglD | - |
Campylobacter jejuni subsp. jejuni |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00025 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 5-methyl-4-((2-methylphenethyl)amino)-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid | |
0.00027 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | ethyl (S)-2-(4-acetamidophenethyl)-4-((2-methoxy-2-phenylethyl)amino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylate | |
0.00028 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 2-(4-acetamidophenethyl)-5-methyl-4-((2-(pyridin-2-yl)ethyl)-amino)thieno[2,3-d]pyrimidine-6-carboxylic acid | |
0.00034 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 5-methyl-2-phenethyl-4-((2-(pyridin-3-yl)ethyl)amino)thieno[2,3-d]pyrimidine-6-carboxylic acid | |
0.00037 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 4-((3,5-dimethoxyphenethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid | |
0.00039 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 4-((3-fluorophenethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid | |
0.00039 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 5-methyl-2-phenethyl-4-((2-(pyridin-4-yl)ethyl)amino)thieno[2,3-d]pyrimidine-6-carboxylic acid | |
0.00042 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 4-((4-fluorophenethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid | |
0.00042 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 5-methyl-4-((3-methylphenethyl)amino)-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid | |
0.00042 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 5-methyl-2-phenethyl-4-((2-(pyridin-2-yl)ethyl)amino)thieno[2,3-d]pyrimidine-6-carboxylic acid | |
0.00042 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | ethyl 4-(((S)-2-methoxy-2-phenylethyl)amino)-5-methyl-2-((R)-2-phenylpropyl)thieno[2,3-d]pyrimidine-6-carboxylate | |
0.00045 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 4-((3-methoxyphenethyl)amino)-5-methyl-2-phenethylthieno-[2,3-d]pyrimidine-6-carboxylic acid | |
0.00046 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 5-methyl-4-(methylamino)-2-(2-(pyridin-2-yl)ethyl)thieno[2,3-d]-pyrimidine-6-carboxylic acid | |
0.00048 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 4-((2-methoxyphenethyl)amino)-5-methyl-2-phenethylthieno-[2,3-d]pyrimidine-6-carboxylic acid | |
0.00048 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 4-((2-fluorophenethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid | |
0.00054 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 4-((4-methoxyphenethyl)amino)-5-methyl-2-phenethylthieno-[2,3-d]pyrimidine-6-carboxylic acid | |
0.00059 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 4-((2-(benzo[d][1,3]dioxol-5-yl)ethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid | |
0.00072 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 5-methyl-4-((4-methylphenethyl)amino)-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid | |
0.00087 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | ethyl 4-(((R)-2-methoxy-2-phenylethyl)amino)-5-methyl-2-((R)-2-phenylpropyl)thieno[2,3-d]pyrimidine-6-carboxylate | |
0.001 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 4-( (2,3-dihydro-1H-inden-2-yl )amino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid | |
0.0011 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 2-(3-methoxyphenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]pyrimidine-6-carboxylic acid | |
0.0011 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | ethyl 4-(((S)-2-methoxy-2-phenylethyl)amino)-5-methyl-2-((S)-2-phenylpropyl)thieno[2,3-d]pyrimidine-6-carboxylate | |
0.0014 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 5-methyl-2-phenethyl-4-(phenethylamino)thieno[2,3-d]-pyrimidine-6-carboxylic acid | |
0.0014 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 2-(4-acetamidophenethyl)-4-((2-aminoethyl)amino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid | |
0.0014 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 2-(3-methoxyphenethyl)-4-(methylamino)thieno[3,2-d]-pyrimidine-6-carboxylic acid | |
0.0016 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 4-((2-aminoethyl)amino)-5-methyl-2-phenethylthieno[2,3-d]-pyrimidine-6-carboxylic acid | |
0.0018 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 2-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-5-methyl-4-(methylamino)-thieno[2,3-d]pyrimidine-6-carboxylic acid | |
0.002 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | ethyl 4-(((R)-2-methoxy-2-phenylethyl)amino)-5-methyl-2-((S)-2-phenylpropyl)thieno[2,3-d]pyrimidine-6-carboxylate | |
0.0021 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 2-(3-chlorophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]-pyrimidine-6-carboxylic acid | |
0.0022 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 5-methyl-4-(methylamino)-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid | |
0.0023 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 2-(3-fluorophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]-pyrimidine-6-carboxylic acid | |
0.0024 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 2-(4-acetamidophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]pyrimidine-6-carboxylic acid | |
0.0035 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 2-(3-acetamidophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]pyrimidine-6-carboxylic acid | |
0.0039 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 4-(methylamino)-2-phenethylthieno[3,2-d]pyrimidine-6-carboxylic acid | |
0.0041 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 5-methyl-4-(methylamino)-2-(4-phenylbutyl)thieno[2,3-d]-pyrimidine-6-carboxylic acid | |
0.0044 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 5-methyl-4-(methylamino)-2-(3-phenylpropyl)thieno[2,3-d]-pyrimidine-6-carboxylic acid | |
0.0045 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 4-(benzylamino)-5-methyl-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid | |
0.0046 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 5-methyl-4-(methylamino)-2-(3-(trifluoromethyl)phenethyl)-thieno[2,3-d]pyrimidine-6-carboxylic acid | |
0.009 | - |
pH 7.8, temperature not specified in the publication | Campylobacter jejuni subsp. jejuni | 2-(2-acetamidophenethyl)-5-methyl-4-(methylamino)thieno[2,3-d]pyrimidine-6-carboxylic acid |